Irf3 CLIA Kit for Mouse(Mus musculus) | EIAab.comIrf3 CLIA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Irf3(Gene name) > Mouse

Irf3 (Gene name),

Interferon regulatory factor 3 (Protein name ), IRF3_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Irf3;

Protein name:

Interferon regulatory factor 3(IRF-3);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; phosphorylation-induced. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with RBCK1. Interacts with TRIM21.

Function:

Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.

Subcellular Location:

Cytoplasm Nucleus Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Protein Attributes:

Sequence length:

419

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

419:

KAYLQDLVED | MDFQATGNI

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF00605

String:

P70671

KEGG:

mmu:54131

SMR:

P70671

UniGene:

Mm.3960

STRING:

10090.ENSMUSP00000103466

Uniprot:

P70671

FOR

ELISA Kit for Mouse IRF-3

Cat.:

E1491m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse IRF-3

Cat.:

E1491h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse IRF-3

Cat.:

E1491b

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse IRF-3

Cat.:

E1491c

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse IRF-3

Cat.:

E1491p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRF-3

Cat.:

U1491h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRF-3

Cat.:

U1491m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRF-3

Cat.:

U1491b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRF-3

Cat.:

U1491c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse IRF-3

Cat.:

U1491p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse IRF-3

Cat.:

P1491Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IRF-3

Cat.:

P1491Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IRF-3

Monoclonal Antibody for Mouse IRF-3

Protein for Mouse IRF-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

Hakem R. , Grossman A. , Antonio L. , Suggs S. , Mak T.W.
Submitted (1996-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Liver.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"IRF-7 is the master regulator of type-I interferon-dependent immune responses."
Honda K. , Yanai H. , Negishi H. , Asagiri M. , Sato M. , Mizutani T. , Shimada N. , Ohba Y. , Takaoka A. , Yoshida N. , Taniguchi T.
Nature434:772-777(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages."
Solis M. , Goubau D. , Romieu-Mourez R. , Genin P. , Civas A. , Hiscott J.
Biochem. Pharmacol.72:1469-1476(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
5.

"Type I interferon gene induction by the interferon regulatory factor family of transcription factors."
Honda K. , Takaoka A. , Taniguchi T.
Immunity25:349-360(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
6.

Honda K. , Takaoka A. , Taniguchi T.
Immunity25:849-849(2006)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
7.

"Trex1 prevents cell-intrinsic initiation of autoimmunity."
Stetson D.B. , Ko J.S. , Heidmann T. , Medzhitov R.
Cell134:587-598(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
8.

"Regulation of immunity and oncogenesis by the IRF transcription factor family."
Savitsky D. , Tamura T. , Yanai H. , Taniguchi T.
Cancer Immunol. Immunother.59:489-510(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
9.

"Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection."
Perwitasari O. , Cho H. , Diamond M.S. , Gale M. Jr.
J. Biol. Chem.286:44412-44423(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION UPON SSRNA VIRAL INFECTION

Product Feedback Wall

* Email:
*Comments: